Calistoga is at the North end of Napa Valley. From the south and east, most visitors take HWY 80 to 29, enter the Valley on 29 through American Canyon and proceed up the Valley on 29 through Napa, Yountville and St. Helena. Traffic on 29 through St. Helena can be congested: the best alternate route is Silverado Trail, which parallels 29 on the east side of the Valley.

If you are traveling from San Francisco, Santa Rosa, or points north on Highway 101, follow US-101 to Mark West Springs Rd in Sonoma County. Take exit 494 from US-101 N and proceed east.